Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology
    2. Genetics and Genomics

    Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

    San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo
    Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent synapse elimination requires caspase-3 activation

    Zhou Yu, Andrian Gutu ... Erin K O'Shea
    Caspase-3 activation links synapse weakening to synapse elimination.
    1. Neuroscience

    Human brain ancestral barcodes

    Darryl Shibata
    A dynamic DNA methylation 'barcode' on the X chromosome can distinguish thousands of individual adult male neurons and may record aspects of their development.
    1. Developmental Biology
    2. Neuroscience

    A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord

    Jelly HM Soffers, Erin Beck ... Haluk Lacin
    A temporally stable and cell-type-specific genetic driver library provides the means to access and manipulate neuronal lineages in the fly nervous system during development and adulthood.
    1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
    Long-range communication between neighboring organs orchestrates the disciplined migration of stem cells.
    1. Developmental Biology

    Oviductin sets the species-specificity of the mammalian zona pellucida

    Daniel de la Fuente, Maria Maroto ... Alfonso Gutierrez-Adan
    The oocyte zona pellucida needs to interact with an oviduct protein called OVGP1 to ensure that only sperm from the same species can fertilize the egg.
    1. Genetics and Genomics

    Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression

    Shengze Yao, Yesu Jeon ... Jeannie T Lee
    Xist RNA’s influence extends beyond the X-chromosome and its autosomal influence can be perturbed genetically and pharmacologically.
    1. Epidemiology and Global Health

    Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar

    Hiam Chemaitelly, Houssein H Ayoub ... Laith J Abu-Raddad
    A pronounced and consistent healthy vaccinee effect has been identified in rigorously conducted vaccine effectiveness studies, specifically within the first 6 months post-vaccination and among older or clinically vulnerable individuals, likely driven by lower vaccination rates among severely ill populations.
    1. Neuroscience

    Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

    Yevheniia Ishchenko, Amanda T Jeng ... Anthony J Koleske
    Heterozygosity for Trio variants leads to overlapping but distinct impacts on behavior, neuronal structure, and synaptic transmission, including newly characterized defects in presynaptic function.
    1. Microbiology and Infectious Disease

    A within-host infection model to explore tolerance and resistance

    David Duneau, Pierre DM Lafont ... Jean-Baptiste Ferdy
    A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of current experimental proxies and proposing new methods to better understand host resistance and disease tolerance.